Background In the yeast Saccharomyces cerevisiae, the presence of high levels of glucose leads to an array of down-regulatory effects known as glucose repression. This process is complex due to the presence of feedback loops and crosstalk between different pathways, complicating the use of intuitive approaches to analyze the system. Results We established a logical model of yeast glucose repression, formalized as a hypergraph. The model was constructed based on verified regulatory interactions and it includes 50 gene transcripts, 22 proteins, 5 metabolites and 118 hyperedges. We computed the logical steady states of all nodes in the network in order to simulate wildtype and deletion mutant responses to different sugar availabilities. Evaluation of the model predictive power was achieved by comparing changes in the logical state of gene nodes with transcriptome data. Overall, we observed 71% true predictions, and analyzed sources of errors and discrepancies for the remaining. Conclusion Though the binary nature of logical (Boolean) models entails inherent limitations, our model constitutes a primary tool for storing regulatory knowledge, searching for incoherencies in hypotheses and evaluating the effect of deleting regulatory elements involved in glucose repression. Helikar Tomas thelika@unmc.edu University of Nebraska - Lincoln 2014-10-31T15:29:36Z 2017-10-16T12:31:16Z

<font face="Georgia" size="2">Extracellular D-glucose</font><div><div><font face="Georgia" size="2">PubChem ID: <span style="line-height: 19px; background-color: rgb(255, 255, 255);">5793</span> </font></div><div><font face="Georgia" size="2"><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">Molecular Formula:</span><span style="line-height: 17px; background-color: rgb(255, 255, 255);"> C</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">6</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">H</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">12</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">O</span><sub style="border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">6</sub><span style="line-height: 17px; background-color: rgb(255, 255, 255);">   </span><span style="border: 0px; outline: 0px; line-height: 17px; vertical-align: baseline; margin: 0px; padding: 0px; background-color: rgb(255, 255, 255);">Molecular Weight:</span><span style="line-height: 17px; background-color: rgb(255, 255, 255);"> 180.15588</span></font></div></div>

2017-10-13T17:04:35Z

\r\n \r\n \r\n <div class="page" title="Page 1">\r\n <div class="section">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p style="font-style: normal;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene: </font></span></p><p style="font-style: normal;"><span style="background-color: rgb(255, 255, 255); font-family: Georgia; font-size: small; line-height: 16px;">High-affinity glucose transporter SNF3</span></p>\r\n \r\n \r\n \r\n <p style="font-style: normal;"><font face="Georgia" size="2">Plasma\r\nmembrane\r\nglucose sensor,\r\nhexotransporter\r\nhomologue</font></p><p><font face="Georgia" size="2">UniProt ID<span style="font-style: oblique;">: </span><span style="font-style: normal; font-weight: normal; background-color: rgb(255, 255, 255);">P10870</span><span style="font-style: oblique;"> </span></font></p><p><font face="Georgia" size="2">Gene Name: SNF3</font></p><p><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851333</span></font></p>\r\n </div>\r\n </div>\r\n </div>\r\n </div>

2017-10-16T12:23:42Z

external galactose

2015-12-19T23:08:51Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene:</font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">5'-AMP-activated protein kinase subunit gamma</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P12904</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: SNF4</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">852763</span></font></div>

2017-10-16T12:17:01Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">cAMP-dependent protein kinase regulatory subunit</font></span><div>\r\n \r\n \r\n \r\n <div class="page" title="Page 3">\r\n <div class="section">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p><font face="Georgia">Reg1 is the\r\nregulatory subunit\r\nthat targets Glc7\r\nto\r\ndephosphorylation\r\nof Snf1</font></p><p><font face="Georgia">UniProt ID: <span style="font-weight: normal; background-color: rgb(255, 255, 255);">P07278</span> </font></p>\r\n </div>\r\n </div>\r\n </div>\r\n </div></div>

2017-10-13T17:04:35Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents two genes: </font></span></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Casein kinase I homolog 1</font></span></div><div><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P23291</span><span style="font-family: Georgia; font-size: small;"> </span></div><div><span style="font-family: Georgia; font-size: small;">Gene Name: YCK1</span></div><div><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856537</span></div><div><div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Casein kinase I homolog 2</font></span></p><p><span style="font-family: Georgia; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P23292</span></p><p><span style="background-color: rgb(255, 255, 255); font-family: Georgia; font-size: small;">Gene Name: YCK2</span></p><p><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">855568</span></p><p><font face="Georgia"><span style="background-color: rgb(255, 255, 255);"><br/></span></font></p>\r\n </div>\r\n </div>\r\n </div>\r\n </div></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Transcription </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">factor, part of the </span><span style="font-size: 13px; font-family: Arial, Verdana;">mediator complex</span></div><div>Mediator of RNA polymerase II transcription subunit 15</div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P19659" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P19659</a></div>

2015-12-19T23:08:51Z

Galactose permease

UniProtKB ID: P13181

2017-10-13T17:25:58Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene: </font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">High-affinity glucose transporter RGT2</font></span><div><span style="font-family: Georgia; font-size: small;">Plasma\r\nmembrane\r\nglucose sensor,\r\nhexotransporter\r\nhomologue</span></div><div><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">Q12300</span><span style="font-family: Georgia; font-size: small;"> </span></div><div><span style="font-family: Georgia; font-size: small;">Gene Name: RGT2</span></div><div><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851417</span></div>

2017-10-16T12:14:15Z

Maltose permease genes (MAL21, MAL41, MAL61, MAL31, MAL11)

2017-10-16T11:06:50Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene: </font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">SCF E3 ubiquitin ligase complex F-box protein GRR1</font></span><div><span style="font-family: Georgia; font-size: small;">F-box protein,\r\ncomponent of the\r\nSCF ubiquitin\r\nligase</span></div><div><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P24814</span><span style="font-family: Georgia; font-size: small;"> </span></div><div><span style="font-family: Georgia; font-size: small;">Gene Name: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 19.49652862548828px;">GRR1</span></div><div><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">853552</span></div>

2015-12-19T23:08:51Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene: </font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Carbon catabolite-derepressing protein kinase</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P06782</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: SNF1</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">852088</span></font></div>

2015-12-19T23:08:51Z 2017-10-16T12:23:42Z

Extracellular maltose

2015-12-19T23:08:51Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">Serine/threonine-protein phosphatase PP1-2</font></span><div>\r\n \r\n \r\n \r\n <div class="page" title="Page 3">\r\n <div class="section">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p><font face="Georgia">Glc7 is protein\r\nphosphatase 1 </font></p>\r\n </div>\r\n </div>\r\n </div>\r\n </div><div style="line-height: normal;"><font face="Georgia"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P32598</span></font></div></div>

2015-12-19T23:08:51Z 2017-10-13T17:34:50Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene of: </font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Glucose transport transcription regulator RGT1</font></span><div><span style="font-family: Georgia; font-size: small;">Transcription\r\nfactor</span></div><div><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P32862</span><span style="font-family: Georgia; font-size: small;"> </span></div><div><span style="font-family: Georgia; font-size: small;">Gene Name: RGT1</span></div><div><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">853828</span></div>

2015-12-19T23:08:51Z

Transcription factor

UniProt ID: P27705

2017-10-16T11:40:45Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Low-affinity glucose transporter HXT3</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P32466</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">HXT3</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851946</span></font></div>

2017-10-16T10:36:26Z

<font face="Arial, Verdana"><span style="font-size: 13px;">Hexotransporter 5</span></font><div><font face="Arial, Verdana"><span style="font-size: 13px;">UniProt AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/P38695" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P38695</a></div>

2015-12-19T23:08:51Z

<div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Represents the gene of the transcription factor: </font></sup></span></div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Transcription corepressor MIG3</span><br/></font><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P39943</span></font></div><div><sup><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene name: MIG3</span></font></sup></div><font face="Georgia" size="2"><sup><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span></sup><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856750</span></font></div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">Protein of </span><span style="font-size: 13px;">Galactose </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">permease </span><div><font face="Arial, Verdana"><span style="font-size: 13px;">UniProt AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/E7Q6K0" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">E7Q6K0</a><font face="Arial, Verdana"><span style="font-size: 13px;"><br/></span></font><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div></div>

2017-10-13T17:54:19Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Represents the transcription factor: </font></sup></span></div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Transcription corepressor MIG3</span><br/></font><div style="font-family: Times; font-size: medium;"><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P39943</span></font></div><div style="font-family: Times; font-size: medium;"><sup><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene name: MIG3</span></font></sup></div><font face="Georgia" size="2"><sup><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span></sup><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856750</span></font>

2017-07-17T14:22:31Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Transcriptional </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">activator of the gene SIP4</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt ID:</span><a href="http://www.uniprot.org/uniprot/P46954" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P46954</a></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">NCBI Gene ID: </span><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">853356</span></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Protein of Galactokinase, </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">posttranslational </span><span style="font-size: 13px; font-family: Arial, Verdana;">regulator of Gal80 </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/C8Z414" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">C8Z414</a></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div>

2015-12-19T23:08:51Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents:</font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Glucose transport transcription regulator RGT1</font></span><div><span style="font-family: Georgia; font-size: small;">Transcription factor</span></div><div><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P32862</span><span style="font-family: Georgia; font-size: small;"> </span></div><div><span style="font-family: Georgia; font-size: small;">Gene Name: RGT1</span></div><div><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">853828</span></div>

2017-10-16T10:50:22Z

<div><strong style="color: rgb(68, 68, 68); font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Regulatory protein CAT8 gene</strong></div><div><font face="Arial, Verdana"><span style="font-size: 13px;">Transcriptional </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">activator </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P39113" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P39113</a></div>

2015-12-19T23:08:51Z

internal galactose

2017-10-13T17:31:50Z

<div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><strong style="color: rgb(68, 68, 68); font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px;">Regulatory protein CAT8</strong></div><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><font face="Arial, Verdana"><span style="font-size: 13px;">Transcriptional </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">activator </span></div><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P39113" style="outline: none; color: rgb(64, 148, 180); text-decoration: none; border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px;">P39113</a></div>

2015-12-19T23:08:51Z

Regulatory protein of gene Transcript SIP4<div>UniProt ID: <a href="http://www.uniprot.org/uniprot/N1P0T7" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">N1P0T7</a></div>

2015-12-19T23:08:51Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents:</font></span></div><span style="font-family: Times; font-size: medium; line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">High-affinity glucose transporter RGT2</font></span><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Plasma membrane glucose sensor, hexotransporter homologue</span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">Q12300</span><span style="font-family: Georgia; font-size: small;"> </span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Gene Name: RGT2</span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851417</span></div>

2017-10-16T12:23:42Z

<div><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 16px;">Casein kinase I homolog 1</span></div><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P23291</span></font></div><div><span style="background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene Name: YCK1</font></span></div><div><font face="Georgia" size="2"><span style="font-weight: normal; background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856537</span></font></div>

2015-12-19T23:08:51Z

<div><ol class="noNumbering molecular_function" style="margin: 0.1em 0px 0.2em; padding: 0px 9px 0px 0.3em;"><li style="text-align: left; word-wrap: break-word; list-style-type: none; margin-top: 0px; min-width: 50%; display: inline-block;"><a href="http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0001104" style="border-bottom-width: 0px; cursor: pointer;">RNA polymerase II transcription cofactor activity</a> protein</li></ol></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div><font face="Arial, Verdana"><span style="font-size: 10pt;">UniProt AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/C8ZHR3" style="font-family: Verdana, Arial, sans-serif; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: 20.081974029541px; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; background-color: rgb(255, 255, 255);">C8ZHR3</a>

2015-12-19T23:08:51Z

<font face="Arial, Verdana" style="color: rgb(79, 79, 79); font-size: 12px; line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><span style="font-size: 13px;">Regulatory proteins of transcriptional </span></font><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">activator of MAL </span><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">genes (MAL23, MAL43, MAL63, MAL33, MAL13)</span><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><br/></span></div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">MAL23p</span></div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/N1P9B3" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">N1P9B3</a></div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);"><br/></span></div><div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">MAL33p</span></div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/D3UF45" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">D3UF45</a></div></div><div><br/></div><div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">MAL13p</span></div><div><span style="color: rgb(79, 79, 79); line-height: 14.4000005722046px; background-color: rgb(255, 255, 255);">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/H0GVH4" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">H0GVH4</a></div></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Regulatory protein of transcription </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">factor, activator of </span><span style="font-size: 13px; font-family: Arial, Verdana;">GAL genes </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/E7KJ64" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">E7KJ64</a></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Melibiase, </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">secreted </span><span style="font-size: 13px; font-family: Arial, Verdana;">galactosidase </span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">UniProt AccessionID: <a href="http://www.uniprot.org/uniprot/P04824" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P04824</a></div>

2017-10-16T11:40:45Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the protein: </font></span></div><span style="font-family: Times; font-size: medium; line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">SCF E3 ubiquitin ligase complex F-box protein GRR1</font></span><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">F-box protein, component of the SCF ubiquitin ligase</span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P24814</span><span style="font-family: Georgia; font-size: small;"> </span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Gene Name: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 19.49652862548828px;">GRR1</span></div><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Gene ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">853552</span></div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 13px;">Gene for regulatory protein transcript Malate synthase </span></font><div><font face="Arial, Verdana"><span style="font-size: 13px;">UniProt ID: </span></font><a href="http://www.uniprot.org/uniprot/P30952" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P30952</a></div><div>NCBI gene ID: <span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">855606</span></div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 13px;">Isocitrate lyase </span></font><div><font face="Arial, Verdana"><span style="font-size: 13px;">UniProt AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/P28240" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P28240</a></div>

2015-12-19T23:08:51Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the gene of:</font></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Protein MTH1</font></span><div><span style="font-family: Georgia; font-size: small;">Regulator of Rgt1\r\nactivity </span><div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P35198</span></font></div></div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: MTH1</span></font></div><div style="line-height: normal;"><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851870</span></font></div></div>

2017-10-16T12:01:48Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">Serine/threonine-protein phosphatase PP1-2</font></span><div><font face="Georgia"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P32598</span></font></div><div><font face="Georgia"><span style="background-color: rgb(255, 255, 255);"> </span></font></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">cAMP-dependent protein kinase regulatory subunit</font></span><div><div class="page" title="Page 3"><div class="section"><div class="layoutArea"><div class="column"><p><font face="Georgia">UniProt ID: <span style="background-color: rgb(255, 255, 255);">P07278</span> </font></p></div></div></div></div></div></div>

2015-12-19T23:08:51Z

<p style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the protein:</font></span></p><p style="font-family: Times; font-size: medium;"><span style="background-color: rgb(255, 255, 255); font-family: Georgia; font-size: small; line-height: 16px;">High-affinity glucose transporter SNF3</span></p><p style="font-family: Times; font-size: medium;"><font face="Georgia" size="2">Plasma membrane glucose sensor, hexotransporter homologue</font></p><p style="font-family: Times; font-size: medium;"><font face="Georgia" size="2">UniProt ID<span style="font-style: oblique;">: </span><span style="background-color: rgb(255, 255, 255);">P10870</span><span style="font-style: oblique;"> </span></font></p><p style="font-family: Times; font-size: medium;"><font face="Georgia" size="2">Gene Name: SNF3</font></p><p style="font-family: Times; font-size: medium;"><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851333</span></font></p>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Transcription </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">factor, activator of </span><span style="font-size: 13px; font-family: Arial, Verdana;">GAL genes </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P04386" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P04386</a></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Phosphoglucomut</span></font><span style="font-size: 13px; font-family: Arial, Verdana;">ase 2 </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P37012" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P37012</a></div>

2015-12-19T23:08:51Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the protein:</font></span></div><span style="font-family: Times; font-size: medium; line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Carbon catabolite-derepressing protein kinase</font></span><div style="font-family: Times; font-size: medium;"><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P06782</span></font></div><div style="font-family: Times; font-size: medium;"><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: SNF1</span></font></div><div style="font-family: Times; font-size: medium;"><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">852088</span></font></div>

2017-10-16T12:15:44Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Galactose-1-</span></font><span style="font-size: 13px; font-family: Arial, Verdana;">phosphate uridyl</span><span style="font-size: 13px; font-family: Arial, Verdana;">transferase </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P08431" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P08431</a></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Transcriptional </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">activator of MAL </span><span style="font-size: 13px; font-family: Arial, Verdana;">genes (MAL23, MAL43, MAL63, MAL33, MAL13)</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">MAL23</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/E9P8G2" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">E9P8G2</a></div><div><br/></div><div><div><span style="font-size: 13px; font-family: Arial, Verdana;">MAL63</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P10508" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P10508</a></div></div><div><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div><div><span style="font-size: 13px; font-family: Arial, Verdana;">MAL33</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P38157" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P38157</a></div></div><div><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div><div><span style="font-size: 13px; font-family: Arial, Verdana;">MAL13</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P53338" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P53338</a></div></div><div><br/></div>

2015-12-19T23:08:51Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Represents the gene of the transcription factor: </font></sup></span></div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Regulatory protein MIG2</span><br/></font><div><font face="Georgia" size="2">UniProt ID: <span style="background-color: rgb(255, 255, 255);">P53035</span></font></div><div><sup><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene name: MIG2</span></font></sup></div><font face="Georgia" size="2"><sup><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span></sup><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">852663</span></font><div style="font-size: 10pt; font-family: Arial, Verdana;"><br/></div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">Protein of </span><span style="font-size: 13px;">Regulator that </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">mediates </span><span style="font-size: 13px; font-family: Arial, Verdana;">galactose induced </span><span style="font-size: 13px; font-family: Arial, Verdana;">inhibition of Gal80 </span><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/C8Z4S9" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">C8Z4S9</a></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Acetyl-coA </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">synthetase </span><span style="font-size: 13px; font-family: Arial, Verdana;">isoenzyme </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;"><br/></span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">Uniprot AccessionID: </span><a href="http://www.uniprot.org/uniprot/Q01574" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">Q01574</a></div>

2015-12-19T23:08:51Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">High-affinity glucose transporter HXT1</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P23585</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">HXT2</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">855023</span></font></div>

2017-10-16T10:25:56Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Regulator that </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">mediates </span><span style="font-size: 13px; font-family: Arial, Verdana;">galactose induced </span><span style="font-size: 13px; font-family: Arial, Verdana;">inhibition of Gal80</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P13045" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P13045</a></div>

2015-12-19T23:08:51Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Hexose transporter HXT8</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P40886</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">HXT8</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">853216</span></font></div>

2015-12-19T23:08:51Z

Putative Open Reading Frames

2015-12-19T23:08:51Z

<div><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255); line-height: 16px;">Invertase 2</span></div><div><font face="Georgia" size="2"><span style="line-height: 16px;">Gene Name: SUC2<br/></span></font><div style="line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P00724</span></font></div><div style="line-height: normal;"><span style="font-family: Georgia; font-size: small;">The invertase catalyzes the hydrolysis of sucrose to\r\nfructose and glucose.  </span></div></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Cytoplasmic, </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">NADP dependent </span><span style="font-size: 13px; font-family: Arial, Verdana;">isocitrate </span><span style="font-size: 13px; font-family: Arial, Verdana;">dehydrogenase</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P41939" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P41939</a><span style="font-family: Arial, Verdana; font-size: 13px;"> </span></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">UDP-glucose-4-</span></font><span style="font-size: 13px; font-family: Arial, Verdana;">epimerase </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span>Q14376</div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">Gene transcript of </span><span style="font-size: 13px;">Succinatefumarate </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">mitochondrial </span><span style="font-size: 13px; font-family: Arial, Verdana;">transporter </span><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt ID:</span><a href="http://www.uniprot.org/uniprot/P33303" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P33303</a></div><div><font face="Arial, Verdana"><span style="font-size: 13px;">NCBI Gene ID: </span></font><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);"> </span><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">853558</span></div>

2015-12-19T23:08:51Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Represents the protein:</font></span></div><span style="font-family: Times; font-size: medium; line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Protein MTH1</font></span><div style="font-family: Times; font-size: medium;"><span style="font-family: Georgia; font-size: small;">Regulator of Rgt1 activity </span><div><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P35198</span></font></div></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: MTH1</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">851870</span></font></div></div>

2017-10-16T12:01:48Z

<font face="Arial, Verdana"><span style="font-size: 13px;">Lactate permease</span></font><div>Carboxylic acid transporter protein homolog<font face="Arial, Verdana"><span style="font-size: 13px;"><br/></span></font><div><font face="Arial, Verdana"><span style="font-size: 13px;">UniProt AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/P36035" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P36035</a></div></div>

2015-12-19T23:08:51Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Low-affinity glucose transporter HXT4</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P32467</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">HXT4</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856492</span></font></div>

2017-10-16T10:50:22Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Low-affinity glucose transporter HXT1</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P32465</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">HXT1</span></font></div><div><font face="Georgia" size="2"><span style="font-weight: normal; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">856494</span></font></div>

2017-10-16T10:12:33Z

Regulatory protein of MalT

2017-10-16T11:35:08Z

<div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Represents the transcription factor: </font></sup></span></div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Regulatory protein MIG1</font></sup></span><div><sup><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P27705</span></font></sup></div><div><sup><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene name: MIG1</span></font></sup></div><div><font face="Georgia" size="2"><sup><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span></sup><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">852848</span></font></div>

2017-10-16T10:50:22Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Galactokinase, </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">posttranslational </span><span style="font-size: 13px; font-family: Arial, Verdana;">regulator of Gal80 </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P04385" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P04385</a></div>

2015-12-19T23:08:51Z

internal maltose

2017-10-16T11:05:28Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Fructose-1,6-</span></font><span style="font-size: 13px; font-family: Arial, Verdana;">bisphosphatase </span></div><div><font face="Arial, Verdana"><span style="font-size: 13px;"><br/></span></font></div><div><font face="Arial, Verdana"><span style="font-size: 13px;">Uniprot AccessionID: </span></font><a href="http://www.uniprot.org/uniprot/P09201" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">P09201</a></div>

2015-12-19T23:08:51Z

<div style="font-family: Times; font-size: medium;"><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><sup><font face="Georgia" size="2">Represents the transcription factor: </font></sup></span></div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Regulatory protein MIG2</span><br/></font><div style="font-family: Times; font-size: medium;"><font face="Georgia" size="2">UniProt ID: <span style="background-color: rgb(255, 255, 255);">P53035</span></font></div><div style="font-family: Times; font-size: medium;"><sup><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene name: MIG2</span></font></sup></div><font face="Georgia" size="2"><sup><span style="background-color: rgb(255, 255, 255);">NCBI Gene ID: </span></sup><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">852663</span></font><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><br/></span></font></div>

2017-10-16T11:54:29Z

<font face="Arial, Verdana"><span style="font-size: 13px;">Maltase</span></font><div><font face="Arial, Verdana"><span style="font-size: 13px;"><br/></span></font></div>

2015-12-19T23:08:51Z

<font face="Arial, Verdana"><span style="font-size: 10pt;">Gene transcript of </span><span style="font-size: 13px;">Phosphoenolpyru</span></font><font face="Arial, Verdana"><span style="font-size: 13px;">vate </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">carboxykinase</span><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P10963" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P10963</a></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">NCBI Gene ID: </span><span style="color: rgb(87, 87, 87); font-family: arial, helvetica, clean, sans-serif; font-size: 12px; line-height: 16.199821472168px; background-color: rgb(213, 222, 227);">853972</span></div>

2015-12-19T23:08:51Z

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Cytoplasmic </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">malate </span><span style="font-size: 13px; font-family: Arial, Verdana;">dehydrogenase </span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">UniProt AccessionID: </span><a href="http://www.uniprot.org/uniprot/P22133" style="text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; font-size: 13px; line-height: 20.081974029541px; background-color: rgb(255, 255, 255);">P22133</a></div>

2015-12-19T23:08:51Z

<div style="font-family: Times;"><font face="Georgia"><span style="line-height: 16px;">Represents the protein:</span></font></div><span style="font-family: Times; line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia">Protein STD1</font></span><div style="font-family: Times;"><span style="font-size: 10pt;"><font face="Georgia">Regulator of Rgt1 activity</font></span></div><div style="font-family: Times;"><font face="Georgia"><span style="font-size: 10pt;">UniProt ID: </span><span style="font-size: 10pt; background-color: rgb(255, 255, 255);">Q02794</span><span style="font-size: 10pt;"> </span></font></div><div style="font-family: Times;"><span style="font-size: 10pt;"><font face="Georgia">Gene Name: STD1</font></span></div><div style="font-family: Times;"><font face="Georgia"><span style="font-size: 10pt;">Gene ID: </span><span style="background-color: rgb(255, 255, 255); font-size: 13.333333969116211px; line-height: 18.88888931274414px;">854212</span></font></div>

2017-10-16T12:23:42Z

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">HXT3 has two negative regulators in this model: Mth1p and Rgt1p [1, 2, 3]. </span>

Mth1 prevents the phosphorylatio and subsequent inactivation of Rgt1p [1,3].  </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);"> Rgt1p represses HXT3 activity by binding to the HXT3 promoter. The repression by Rgt1 reported is probably by no means the only regulatory mechanism controlling this gene [1,2]. </span>

S_12 1 S_55 1

Rgt1p negatively regulates HXT5 [1, 2]

HXT5 is repressed by Rgt1 [1, 2]

S_12 1

<font face="Georgia" style="color: rgb(79, 79, 79); font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">MIG3 is repressed by Rgt1 [1,2].</font><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Helvetica; font-size: 8pt; background-color: rgb(255, 255, 255);"> </span>

<font face="Georgia" style="color: rgb(79, 79, 79); font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The regulation of Mig3 is not fully understood, however, it is known to be regulated on the transcriptional level by Rgt1 [2]. MIG3 is repressed by Rgt1 [1,2].</font><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Helvetica; font-size: 8pt; background-color: rgb(255, 255, 255);"> </span>

S_12 1

GAL2 positively regulates Gal2p [1]

S_32 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Mig3p is activated by MIG3 and deactivated by Snf1p [1, 2, 3]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Inhibited by phosphorylation by Snf1 [1,3].</span>

<span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-size: small; font-family: Georgia; background-color: rgb(255, 255, 255);">Assuming that Mig1 is not post-translationally regulated., a</span><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-size: small; font-family: Georgia; background-color: rgb(255, 255, 255);">ctivation of the gene MIG1 produces the protein product MIG1p [1,2].</span>

S_7 1 S_35 1

Activated by Cat8p [1, 2, 3, 4]

<font face="Arial, Verdana"><span style="font-size: 10pt;">Activated by h</span><span style="font-size: 13px;">omologue of Cat8, possibly with a more specific </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">consensus sequence [1, 2, 3, 4]</span>

S_16 1

GAL1 positively regulates Gal1p [1]

S_65 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">RGT1 and either Mth1p or Std1p must be active to activate Rgt1p [1, 2, 3, 4].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The gene, RGT1 must be active for translation of its product to occur [1, 2,3,4]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Rgt1p only function as a repressor when Mth1 OR Std1 is present [1,2,3,4].  </span>

S_64 1 S_55 1 S_73 1

Mig1p negatively regulates Cat8 [1, 2, 3, 4]

Cat8 is repressed by Mig1p [1, 2, 3, 4]

S_63 1

Gal2p positively regulates galactose_int [1]. Galactose_ext positively regulates galactose_int [1]

external galactose activates internal glucose [1]

Gal2p positively regulates galactose_int [1]

S_5 1 S_8 1

Snf1p positively regulates Cat8p [1]. CAT8 positively regulates Cat8p [1]

CAT8 positively regulates Cat8p [1]

Snf1p positively regulates Cat8p [1]

S_13 1 S_35 1

Sn1p positively regulates Sip4p [1]. SIP4 positively regulates Sip4p [1]

SIP4 positively regulates Sip4p [1]

Sn1p positively regulates Sip4p [1]

S_10 1 S_35 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Both extracellular glucose and RGT2 must be active for Rgt2p to be activated [1, 2, 3, 4, 5, 6].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Activated by extracellular glucose on the protein level [1,2,3,4,5,6].</span>

S_1 1 S_37 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">YCK1/2 is a positive regulator of Yck1p [1, 2, 3]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Activation of the gene YCK1/YCK2 produces the protein product Yck1p [1,2,3]. The protein is encoded in two isoformes by </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">YCK</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">1 and </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">YCK</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">2 [1].</span>

S_21 1

GAL11 positively regulates Gal11p [1]

S_23 1

maltose_int positively regulates MalRp [1]. MALR positively regulates MalRp [1]

maltose_int positively regulates MalRp [1]

MALR positively regulates MalRp [1]

S_39 1 S_66 1

GAL4 positively regulates Gal4p [1]. Gal80p negatively regulates Gal4p [1].

GAL4 positively regulates Gal4p [1]

Gal80p negatively regulates Gal4p [1]

S_33 1 S_45 1

Gal4p positively regulates GAL4 [1, 2, 3]. Mig1p negatively regulates MEL1 [1, 4, 5].

<div><font face="Arial, Verdana"><span style="font-size: 13px;">MEL1 is activated by </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">Gal4 [1, 2, 3]</span></div>

<font face="Arial, Verdana"><span style="font-size: 10pt;">MEL1 is r</span><span style="font-size: 13px;">epressed by </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">Mig1 </span><span style="font-size: 13px; font-family: Arial, Verdana;">(putatively) [1, 4, 5]</span>

S_24 1 S_24 1 S_63 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">GRR1 must be active for SCF_grr1 to be active [1, 2].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The gene, Grr1 must be active for translation of its product to occur [1, 2].</span>

S_47 1

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Cat8p positively regulates MLS1 [1, 2, 3]. Sip4p</span></font><span style="font-family: Arial, Verdana; font-size: 13px;"> positively regulates MLS1 [1, 2, 3].</span></div>

<font face="Arial, Verdana" style="font-size: medium;"><span style="font-size: 13px;">Here it assumed that either Cat8 or Sip4 can activate gene expression. However, Sip4 </span></font>expression is controlled by Cat8 in wild type cells [1, 2, 3]

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Here it assumed that either Cat8 or Sip4 can activate gene expression. However, Sip4 </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">expression is controlled by Cat8 in wild type cells [1, 2, 3]</span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div>

S_17 1 S_16 1

Cat8p positively regulates ICL1 [1, 2, 3]. Sip4p positively regulates ICL1 [1, 2, 3].

S_16 1 S_17 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Repressed by Mig21 and Mig2 [1, 2].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">It is not entirely clear to the author whether Mig2 is a significant factor in the repression of </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">MTH1</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">. Here it is supposed that either Mig1 or Mig2 should be inactive for the gene to be derepressed [1].  Repressed by Mig2 [1,2].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Repressed by Mig1 [1,2].</span>

S_63 1 S_68 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">To activate the Glc7Reg1 complex, extracellular glucose must be present as well as the components of the complex. In this model, Glc7 AND Glucose_ext AND Reg1 must be active to activate Glc7Reg1 [1,2,3,4]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The response to extracellular glucose is complex and not fully understood and is therefore not explicitly included the present model. However it is known that an increase in extracellular glucose leads to the activation of Glc7-Reg1 complex [1,2,3,4].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Reg1 is the regulatory subunit that targets Glc7 and activates Glc7 complex [1,2,3,4].  </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Glc7 is protein phosphatase 1 and must be present to form an active complex with Reg1 [1,2,3,4].</span>

S_58 1 S_1 1 S_14 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Glucose_ext and SNF3 are required to activate Snf3p [1, 2, 3, 4, 5, 6].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The gene, SNF3 must be active for translation of its product to occur [1, 2,3,4,5,6]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Snf3p is activated by glucose on the protein level [1,2,3,4,5,6]. </span>

S_1 1 S_3 1

GAL4 is negatively regulated by Mig1p [1, 2, 3].

GAL4 is repressed by Mig1p [1, 2, 3]

S_63 1

Gal4p positively regulates GAL5 [1, 2, 3].

GAL5 is activated by GAL4 [1, 2, 3]

S_24 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">SNF1 and SNF4 must both be present to activate Snf1p. Glc7Reg1 is a negative regulator dominant over both activators [1, 2, 3].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">A regulatory subunit which is essential for Snf1 activity is encoded by SNF4 [1,2]. SNF4 activates Snf1p [1]. </span>

S_50 1 S_6 1 S_30 1

GAL7 is activated by GAL4 [1, 2, 3]

S_33 1

Mig1p negatively regulates MALR [1, 2, 3]

MALR is repressed by MIG1 [1, 2, 3]

S_63 1

<font face="Georgia" size="2" style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">MIG2 is repressed by Rgt1 [1,2].</font><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Helvetica; font-size: 8pt; background-color: rgb(255, 255, 255);"> </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The regulation of Mig2 is not fully understood, however, it is known to be regulated on the transcriptional level by Rgt1 [2]. MIG2 is repressed by Rgt1 [1,2].</span>

S_12 1

GAL3 in conjunction with galactose_int positively regulates Gal3p [1]

S_44 1 S_15 1

Cat8p activates ACS1 [1, 2].

S_16 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">HXT2 is negatively regulated by Mig1p AND Rgt1p [1, 2, 3]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The repression by Rgt1 reported is probably by no means the only regulatory mechanism controlling this gene [1,3]. Here it is assumed that Rgt1 can act as a repressor in the presence of either Mth1 OR Std1 (Mth1 and Std1 are not part of the expression since Rgt1 is only active if at least one of the two is present) [1]</span>

S_63 1 S_12 1

Mig1 negatively regulates GAL3 [1, 2, 3]

<div><font face="Arial, Verdana"><span style="font-size: 13px;">GAL3 is repressed by </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">Mig1 [1, 2, 3]</span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div>

S_63 1

<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">GAL80 positively regulates Gal80p [1]. </span>Gal3p negatively regulates Gal80p [1]. Gal1p negatively regulates Gal80p [1].

Gal3p negatively regulates Gal80p [1]

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Gal1 is probably only plays a minor role in Gal80 inhibition in </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">the WT [1]</span></div><div><span style="font-size: 13px; font-family: Arial, Verdana;">GAL1 must be present to inhibit Gal80p [1].</span></div>

S_60 1 S_41 1 S_11 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Rgt1p is an inhibitor of HXT8 [1,2]</span>

S_12 1

RGT negatively regulates the 4ORFs [1, 2].

<div><font face="Arial, Verdana"><span style="font-size: 13px;">Open reading frames encoding unknown gene </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">products, but which were found by (Kaniak et al., </span><span style="font-size: 13px; font-family: Arial, Verdana;">2004) to be repressed by Rgt1. [1, 2]</span></div>

S_64 1

<font face="Georgia" size="2" style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Mig1p and Mig2p are negative regulators of Suc2 </font><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">[1,2,3]</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Acording to Klein et al (1999) the invertase actually increases significantly in absence of </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">mig1</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">, and a further increase is seen in</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">the absence of </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">mig1</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);"> and </span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; font-style: oblique; background-color: rgb(255, 255, 255);">mig2</span><span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">. - Similar results have been found by Lutfiyya et al., although the effect of single knockouts was found to be less significant (Lutfiyya et al., 1998) [1,2,3].</span>

S_63 1 S_68 1

Cat8p positively regulates IDP2 [1, 2]

IDP2 is activated by CAT8 [1, 2]

S_16 1

GAL10 is activated by GAL4 [1, 2, 3]

S_33 1

SFC1 is activated by Cat8p [1, 2].

SFC1 is activated by Cat8p [1, 2]

S_16 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">MTH1 activates Mth1p, while Rgt2p, SCF_grr1, Snf3p, and Yck1p are negative regulators of Mth1p [1, 2, 3, 4, 5, 6].</span>

<span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">The </span><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">Mth1 protein degradation at the proteasome</span><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);"> is mediated in the presence of glucose through subsequent interactions with SCF-Grr1 [1,2,3,4,5,6]</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The Mth1 protein degradation at the proteasome is mediated in the presence of glucose through subsequent interactions with Rgt2 [1,2,3,4,5,6]. </span>

S_29 1 S_26 1 S_29 1 S_18 1 S_31 1 S_29 1 S_19 1

JEN1 is activated by Cat8p [1, 2]

JEN1 is activated by CAT8 [1, 2]

S_16 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Rgt1p and Mig1p are both negative regulators of HXT4 in the presence of Mth1p [1, 2, 3, 4]</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">According to Kim et al. (2006), Mth1, but not Std1, is involved in Rgt1 repression of HXT [1,2,3].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Repressed by Rgt1 in the presence of active Mth1 [1,3].</span>

S_63 1 S_12 1 S_55 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">HXT1 is repressed by Rgt1 in the presence of Std1 or Mth1 [1].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Repression of this transporter apparently requires either Mth1 or Std1 aside from Rgt1 [1,3]. </span>

S_12 1 S_55 1 S_73 1

MALT positively regulates MalTp [1]

S_38 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Mig1p is activated by MIG1 and deactivated by Snf1p [1, 2, 3].</span>

Transcription of the MIG1 leads to Mig1p production.

S_69 1 S_35 1

GAL1 is positively regulated by Gal4p [1, 2]. GAL1 is negatively regulated by Mig1p [1, 2, 3]

<div><font face="Arial, Verdana"><span style="font-size: 13px;">GAL1 is activated by </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">Gal4 [1, 2]</span></div>

<font face="Arial, Verdana"><span style="font-size: 10pt;">GAL1 is r</span><span style="font-size: 13px;">epressed by </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">Mig1 [1, 2, 3]</span><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><br/></div>

S_24 1 S_63 1

MalTp positively regulates maltose_int [1]. Maltose_ext positively regulates maltose_int [1]

maltose_ext positively regulates maltose_int [1]

MalTp positively regulates maltose_int [1]

S_56 1 S_62 1

Cat8p positively regulates FBP1 [1, 2, 3]. Sip4p positively regulates FBP1 [1, 2, 3].

S_16 1 S_17 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">MIG2 activates Mig2p [1, 2, 3].</span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">Assuming that Mig2 is not post-translationally regulated., activation of the gene MIG2 produces the protein product MIG2p [1,2,3].</span>

S_40 1

MalRp positively regulates MALS [1, 2, 3]. Mig1p negatively regulates MALS [1, 2, 3].

Transcriptionally activated by MalR [1, 2, 3]

Repressed by Mig1 [1, 2, 3]

S_22 1 S_63 1

Cat8p activates PCK1 [1, 2].

<font face="Arial, Verdana"><span style="font-size: 10pt;">Cat8p </span><span style="font-size: 13px;">Catalyzes the decarboxylation of oxaloacetate to </span></font><span style="font-size: 13px; font-family: Arial, Verdana;">yield PEP via ATP consumption in the </span><span style="font-size: 13px; font-family: Arial, Verdana;">gluconeogenesis. [1, 2]</span>

S_16 1

Cat8p positively regulates MDH2 [1, 2, 3]. Sip4p positively regulates MDH2 [1, 2, 3].

S_16 1 S_17 1

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">STD1 activates Std1p, while Rgt2p, SCF_grr1, Snf3p, and Yck1p are negative regulators of Std1p [1, 2, 3, 4, 5, 6].</span>

<span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-size: small; font-family: Georgia; background-color: rgb(255, 255, 255);">The Std</span><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-size: small; font-family: Georgia; background-color: rgb(255, 255, 255);">1 protein degradation at the proteasome</span><span style="color: rgb(79, 79, 79); line-height: 18px; orphans: 3; widows: 3; font-size: small; font-family: Georgia; background-color: rgb(255, 255, 255);"> is mediated in the presence of glucose through subsequent interactions with Snf3 [1,2,3,4,5,6]. </span>

<span style="color: rgb(79, 79, 79); font-family: Georgia; font-size: small; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">The Std1 protein degradation at the proteasome is mediated in the presence of glucose through subsequent interactions with Rgt2 [1,2,3,4,5,6]. </span>

S_52 1 S_19 1 S_52 1 S_31 1 S_18 1 S_52 1 S_26 1